equine sarcoid

Statistical assessment of risk for the clinical management of equine sarcoids in a population of Equus asinus

Citation

Stuart W. Reid, George Gettingby. Statistical assessment of risk for the clinical management of equine sarcoids in a population of Equus asinus. Preventive Veterinary Medicine. 26:2. 87-95.

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Publication details
Volume: 
26
Issue: 
2
Page numbers: 
87-95
DOI number: 
10.1016/0167-5877(95)00521-8
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Sarcoids: Clinical epidemiology, principal effects and treatment responses

Citation

G. Ayele, Feseha Gebreab, E. Bojia, Mulugeta Getachew, Alemayehu Fanta, Mersha Tesfaye, B. Amare, N. Dereje, C. Chala, A. Asefa, Joe Anzuino, Andrew F. Trawford. November 2006. Sarcoids: Clinical epidemiology, principal effects and treatment responses. Presented at 5th International Colloquium on Working Equines. (30 October - 2 November 2006). Addis Ababa, Ethiopia. 5.

Authors
Presentation details
Date presented: 
Wednesday 29 November 2006
Proceedings
Volume: 
5
Publisher: 
The Donkey Sanctuary
Publication date: 
29 November 2006

Vaccination of sarcoid-bearing donkeys with chimeric virus-like particles of Bovine Papillomavirus Type 1

Citation

S. G. Ashrafi, K. Piuko, Faith A. Burden, ZhengQiang Yuan, Elizabeth A. Gault, Matthias Müller, Andrew F. Trawford, Stuart W. Reid, Lubna Nasir, M. Saveria Campo. January 2008. Vaccination of sarcoid-bearing donkeys with chimeric virus-like particles of Bovine Papillomavirus Type 1. Journal of General Virology. 89:1. 148-157.

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Publication details
Publication date: 
1 January 2008
Volume: 
89
Issue: 
1
Page numbers: 
148-157
DOI number: 
10.1099/vir.0.83267-0
Abstract

Equine sarcoids are fibroblastic skin tumours affecting equids worldwide. While the pathogenesis is not entirely understood, infection with bovine papillomavirus (BPV) type 1 (and less commonly type 2) has been implicated as a major factor in the disease process. Sarcoids very seldom regress and in fact often recrudesce following therapy. Nothing is known about the immune response of the equine host to BPV. Given that the viral genes are expressed in sarcoids, it is reasonable to assume that vaccination of animals against the expressed viral proteins would lead to the induction of an immune response against the antigens and possible tumour rejection. To this end we vaccinated sarcoid-bearing donkeys in a placebo-controlled trial using chimeric virus-like particles (CVLPs) comprising BPV-1 L1 and E7 proteins. The results show a tendency towards enhanced tumour regression and reduced progression in the vaccinated group compared to control animals. Although promising, further studies are required with larger animal groups to definitely conclude that vaccination with CVLPs is a potential therapy for the induction of sarcoid regression.

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The detection of Bovine Papillomavirus Type 1 DNA in flies

Citation

Margaret Finlay, ZhengQiang Yuan, Faith A. Burden, Andrew F. Trawford, I. M. Morgan, M. Saveria Campo, Lubna Nasir. September 2009. The detection of Bovine Papillomavirus Type 1 DNA in flies. Virus Research. 144:1-2. 315-317.

Authors
Publication details
Publication date: 
1 September 2009
Journal: 
Virus Research
Volume: 
144
Issue: 
1-2
Page numbers: 
315-317
DOI number: 
10.1016/j.virusres.2009.04.015
Abstract

BPVs are double stranded DNA viruses that can infect several species other than the natural host, cattle, including equids. In equids, BPV-1, and, less commonly BPV-2, infection gives rise to fibroblastic tumours of the skin. Whilst a causal relationship between BPV-1/2 and equine sarcoids is now well established, how the disease is transmitted is not known. In this study we show BPV-1 DNA can be detected in flies trapped in the proximity of sarcoid-affected animals. Sequence analysis of the BPV-1 LCR from flies indicates that flies harbour BPV-1 LCR sequence variants II and IV which are commonly detected in equine sarcoids. These data suggest that flies may be able to transmit BPV-1 between equids.

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