Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys

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Non-DS research

This publication may be of interest, however, The Donkey Sanctuary has had no direct involvement with this publication, and claims no credit for published results.

To our best knowledge donkey welfare has not been compromised, and the following published research is furthering the understanding and respect of donkeys worldwide.

Citation

Melissa D. Sinclair, Katrina L. Mealey, Nora Matthews, Ken E. Peck, Tex S. Taylor, Brad S. Bennett. July 2006. Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys. American Journal of Veterinary Research. 67:6. 1082-1085.

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Publication details
Publication date: 
1 July 2006
Volume: 
67
Issue: 
6
Page numbers: 
1082-1085
DOI number: 
10.2460/ajvr.67.6.1082
Abstract

Objective: To determine the disposition of a bolus of meloxicam (administered IV) in horses and donkeys (Equus asinus) and compare the relative pharmacokinetic variables between the species.

Animals: 5 clinically normal horses and 5 clinically normal donkeys.

Procedures: Blood samples were collected before and after IV administration of a bolus of meloxicam (0.6 mg/kg). Serum meloxicam concentrations were determined in triplicate via high-performance liquid chromatography. The serum concentration-time curve for each horse and donkey was analyzed separately to estimate standard noncompartmental pharmacokinetic variables.

Results: In horses and donkeys, mean +/- SD area under the curve was 18.8 +/- 7.31 microg/mL/h and 4.6 +/- 2.55 microg/mL/h, respectively; mean residence time (MRT) was 9.6 +/- 9.24 hours and 0.6 +/- 0.36 hours, respectively. Total body clearance (CL(T)) was 34.7 +/- 9.21 mL/kg/h in horses and 187.9 +/- 147.26 mL/kg/h in donkeys. Volume of distribution at steady state (VD(SS)) was 270 +/- 160.5 mL/kg in horses and 93.2 +/- 33.74 mL/kg in donkeys. All values, except VD(SS), were significantly different between donkeys and horses.

Conclusions and clinical relevance: The small VD(SS) of meloxicam in horses and donkeys (attributed to high protein binding) was similar to values determined for other nonsteroidal anti-inflammatory drugs. Compared with other species, horses had a much shorter MRT and greater CL(T) for meloxicam, indicating a rapid elimination of the drug from plasma; the even shorter MRT and greater CL(T) of meloxicam in donkeys, compared with horses, may make the use of the drug in this species impractical.

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