Out of Africa – evaluation of bioactive plant extracts for endoparasite control

Status
Status: 
Ongoing
Applicants
Collaborators
Researchers
Details
When conducted: 
1 October 2010 - 30 November 2012
Country: 
United Kingdom
Ethiopia
Core methodology: 
Participatory research, randomised controlled trials in vitro and in vivo evaluation of bioactive plant extracts (BPEs).
Aims: 
1) To obtain locally sourced, sustainable plant-based anthelmintics currently used for treating donkeys for nematode infections in sub-Saharan Africa (Ethiopia). 2) To evaluate bioactive plant extracts in vitro, both from the UK (identified previously as having anti-nematode potential in sheep) and Ethiopia (sourced in point 1), for efficacy against strongyle eggs and third stage larvae (L3) using the egg hatch assay (EHA) and L3 migration assay (LMA), respectively. 3) To test selected plants in vivo in donkeys in the UK and Ethiopia for efficacy against gastrointestinal nematodes using a faecal egg count reduction test (FECRT) at the Donkey Sanctuary, UK and a randomised, placebo controlled, trial in Ethiopia.