Improving sarcoid management: an epidemiological and molecular approach

Status
Status: 
Ongoing
Applicants
Collaborators
Researchers
Award types
Donkey Sanctuary awards: 
PhD
Details
Country: 
United Kingdom
Core methodology: 
1) Database mining to identify risk factors 2) Donkey tracing and behavioural monitoring 3) Development of transcriptomic biomarkers via a)sarcoid sample collection and mRNA sequencing; and b) Sequencing of Bovine Papillomavirus (BPV) from sarcoid tissue Data will be analysed by a team at Glasgow University aiming to provide an insight into the underlying pathological process at a molecular and cellular level, which will explain the differences among tumour types. A risk modelling analysis framework will also be developed.
Aims: 
In this multi-disciplinary project we aim to identify the risk factors for sarcoids and to identify specific ‘molecular signatures’ that will aid in the management and treatment of sarcoids in donkeys.
Objectives: 
1) Identify epidemiological factors associated with development of sarcoids by using and enhancing the available Donkey Sanctuary clinical database; 2) Identify key risk factors associated with development of sarcoids by mapping animal contact, location and key movements 3) Use RNA transcriptome profiling and viral genotyping to differentiate sarcoid types and use this data to develop prognostic biomarkers of recurrent/non-recurrent sarcoids to aid in treatment management